ⒸPathologynuggets.blogspot.com Notes to review for medical students, residents, and doctors. Risk Factors: Diabetes mellitus, Chronic pancreatitis, Hereditary Pancreatitis, Cigarette Smoking Courvoisier Sign of Pancreatic Cancer: Pancreatic cancer has jaundice which is painless, and gallbladder is palpable below right costal margin. Trousseau Sign of Pancreatic Carcinoma: It is associated with recurrent migratory thrombophlebitis. Other findings suggestive of this cancer are: weight loss, anorexia, dull abdominal pain which is worse at night. Other important associations include new onset Diabetes Mellitus  and non-bacterial thrombotic endocarditis . Diagnosis: Imaging by Ultrasonography or CT scan is test of choice. CT Scan shows "double-duct sign". Definitive diagnosis is by biopsy and histologic examination. If these tests are inconclusive, Endoscopic ultrasound or ERCP with brushings/biopsy for histopathology can be done. Role of CA 19-9 in pancreatic cancer: It does