This post is about nucleosides, nucleotides, and nucleic acids. It is often confusing for students to remember and tell the differences between them. Let's look at what they are. A nitrogenous base, sugar, which can be either deoxyribose or ribose sugar, and phosphate are building blocks of nucleic acids, DNA, and RNA. Nitrogenous bases are  Adenine, Guanine, Cytosine, Thymine, and Uracil Among these bases, Adenine and guanine are known as Purines. Similarly, Cytosine, Uracil, and Thymine are Pyrimidines. How to remember them?  The Mnemonic is "Pure as gold." for purines and C, U, T, for pyrimidines. When these bases are combined with sugar, they are then known as nucleosides, "Remember sides with sugar! " Nucleosides have names either ending in "sines" or "dines" Adenosine,  Guanosine, Cytidine, Thymidine, Uridine. When phosphate is added to nucleosides, it gives nucleotides. Remember " Tides with Phosphate " These can be monopho...

 pathologynuggets.blogsspot.com notes on AUB. Abnormal uterine bleeding can be either Heavy menstrual bleed or Intermenstrual bleeding. In heavy menstrual bleeding, there is excessive or prolonged bleeding during periods. It occurs during regular menstrual cycles.  In contrast, bleeding occurs irregularly between menstrual cycles, in intermenstrual bleeding.  If A is one cycle and B is the next menstrual cycle, in HMB, heavy bleeding or an increased amount of bleed occurs in these regular cycles, while in intermenstrual bleeding, the bleeding occurs, in between, these cycles. Other types of abnormal bleeding include post-coital bleed and postmenopausal bleeding. AUB mnemonic  One of the classification systems for AUB  is the mnemonic PALM COEIN. Among these, PALM represents structural causes, and COEIN represents non-structural causes. PALM stands for polyp, adenomyosis, leiomyoma, and malignancy Similarly, COEIN stands for coagulopathy, ovulatory cause, endome...

 pathologynuggets.blogspot.com 2023 ECG interpretation is an important skill for any healthcare professional. How to calculate the Heart rate? Several methods can be employed to ascertain the heart rate.  One straightforward and expedient approach involves  Identifying a QRS complex aligned with a prominent vertical grid line. followed by counting the number of large squares to the subsequent QRS complex. Dividing 300 by this count provides the heart rate.  Example: In the presented ECG, there are 2 large squares between QRS complexes, resulting in a calculated heart rate of 150 beats per minute. Note: This method only works if the paper speed is set to standard i.e. 25mm/second. At the standard speed of 25mm/s,      each large square = 0.2 second     each small square = 0.04 second Similarly, this method only works if the heart rhythm is regular. You can find how to assess heart rhythm and calculate heart rate for abnormal rhythm in this ar...

  Pathologynuggets.blogspot.com 2023 1. What type of fracture occurs when the bone breaks but does not penetrate the skin? A. Compound fracture B. Greenstick fracture C. Closed fracture D. Spiral fracture __________ The answer is at the end of this article. Types of fractures Based on the position of the bony fragments after fracture, fractures can be either displaced or non-displaced.      Displaced Fracture         The bone breaks into two or more pieces and shifts out of alignment.      Non-Displaced Fracture      The bone breaks without shifting out of alignment. Based on the involvement of overlying skin, fractures can be either closed or open.      Closed Fracture The skin remains intact despite the bone breakage.      Open Fracture The bone breaks through the skin, requiring immediate medical attention as it is considered a medical emergency. Avulsion Fracture occurs whe...

  ⒸPathologynuggets.blogspot.com Notes to review for medical students, residents, and doctors. Risk Factors: Diabetes mellitus, Chronic pancreatitis, Hereditary Pancreatitis, Cigarette Smoking Courvoisier Sign of Pancreatic Cancer: Pancreatic cancer has jaundice which is painless, and gallbladder is palpable below right costal margin. Trousseau Sign of Pancreatic Carcinoma: It is associated with recurrent migratory thrombophlebitis. Other findings suggestive of this cancer are: weight loss, anorexia, dull abdominal pain which is worse at night. Other important associations include new onset Diabetes Mellitus  and non-bacterial thrombotic endocarditis . Diagnosis: Imaging by Ultrasonography or CT scan is test of choice. CT Scan shows "double-duct sign". Definitive diagnosis is by biopsy and histologic examination. If these tests are inconclusive, Endoscopic ultrasound or ERCP with brushings/biopsy for histopathology can be done. Role of CA 19-9 in pancreatic cancer: It does ...

  ⒸPathologynuggets. Notes to review for medical students, residents, and doctors. Vasculitides are autoimmuine disorders characterized by inflammation of blood vessels. Most of them are chronic systemic disorders that affect the multiple systems and should be considered in differential diagnoses of any multisystem illness. Vasculitis can be divided into large vessel, medium vessel or small vessel vasculitis based on the size of the vessels involved. Large Vessel Vasculitis ‌Giant cell arterities or Temporal arteritis Takayasu arterities Medium Vessel Vasculitis ‌Polyarterities Nodosa Kawasaki Disease Small Vessel Vasculitis ‌Granulomatosis with Polyangitis(GPA) ‌Microscopic polyangitis (MPA) ‌Eosinophilic Granulomatosis with Polyangitis (EGPA)               **  Small vessel vasculitides GPA, MPA and EGPA are also known as ANCA                        ...

Diffuse axonal injury is a type of brain injury caused by trauma in cases of sudden acceleration-deceleration. It is commonly seen in cases of high-speed vehicle accidents.  Which areas of the brain are affected by this type of injury? It mostly affects the areas where brain matter density difference is maximum. Therefore, the most commonly affected areas are gray-white junctions. It affects white matter nerve fiber tracts in these regions. Clinical Findings: Although the findings can vary from insignificant to comatose state, most cases are classified as severe with a GCS score of less than 8. Symptoms include  headache,  dizziness,  nausea, vomiting,  loss of consciousness, etc File :  Compare SWI and GRE Trauma.png Source: Karen Tong Author: SBarnes CC  Attribution-Share Alike 3.0 Unported Diagnosis: Diffuse axonal injury is diagnosed clinically. The clinical findings in these patients are out of proportion to CT Imaging findings. The patient is unc...